Abstract: Coal mine fan plays an important role in coal mine production, and the fan main spindle was the core part of the fan. Aimed at the problem of whether the radial load and axial load will lead to the damage of the fan spindle, according to the actual production environment and conditions of coal mine, the model of axial flow coal mine fan was constructed, the static analysis of the fan spindle was carried out, according to the phenomenon of stress concentration in spindle statics analysis, the solution was proposed. The fan spindle was optimized and the static analysis was carried out again to eliminate the stress concentration phenomenon. The strength and stiffness properties of the fan spindle were tested by modal analysis. Finally, the simulation results were verified by building a test platform. The results showed that when the radial and axial load of the fan spindle increases at the same time, the fan spindle could operate safely and reliably in the working process.