Abstract: In order to solve the problem of rapid oxidation of coal seam in Jinqiu Coal mine, a combination of removal method and drilling detection was used to quickly lock the dangerous area, and corresponding treatment measures were proposed for each oxidation cause and applied on site. Finally, a underground fire detection system and fire extinguishing system were established, and fire prevention and control plans were proposed for key areas. The results show that: in view of the rapid oxidation of coal and rock caused by water leaching media in the goaf of 12306 working face, the treatment plan of spraying inhibitor + grouting is reduced to the lowest value on the 13th day, and then the CO concentration is maintained in the range of 0.0015%～0.0043%. In view of the situation that supporting coal pillar is left in the goaf of the working face 12307, a concrete wall with a thickness of 30cm is poured around the coal pillar, and the treatment plan of grouting + nitrogen decaying goaf is adopted. It is found that the sealing wall is reinforced after the CO concentration in the goaf drops shockingly, and finally drops to the lowest value on the 12th day. The CO concentration is maintained in the range of 0.0017%～0.0041%.