Abstract: The traditional ventilation system network solution technology has problems such as non-intuitive and cumbersome calculation procedures, which increases the workload of ventilation system optimization. Taking the ventilation system of a mine as an example, a series of optimization schemes of ventilation system are put forward in view of the low efficiency of coal flow transportation system in the four-mining area, the upcoming penetration of new working face and the increase of air demand in the mining area. By using the three-dimensional ventilation simulation software ( Ventsim ) to establish the three-dimensional model of the whole mine, the optimization effect of the mine ventilation system before and after the implementation of the optimization scheme of the four-mining areas, especially the ventilation system of the four-mining areas, is compared and analyzed. The optimization scheme of the four-mining areas can effectively solve the transportation and ventilation problems existing in the four-mining areas.